Structure provides clues

Genome-Based Sexing Provides Clues about Behavior and Social Structure in the Woolly Mammoth.

While present-day taxa are valuable proxies for understanding the biology of extinct species, it is also crucial to examine physical remains in order to obtain a more comprehensive view of their behavior, social structure, and life histories [1, 2]. For example, information on demographic parameters such as age distribution and sex ratios in fossil assemblages can be used to accurately infer so...

The structure of Enterococcus faecalis thymidylate synthase provides clues about folate bacterial metabolism.

Drug resistance to therapeutic antibiotics poses a challenge to the identification of novel targets and drugs for the treatment of infectious diseases. Infections caused by Enterococcus faecalis are a major health problem. Thymidylate synthase (TS) from E. faecalis is a potential target for antibacterial therapy. The X-ray crystallographic structure of E. faecalis thymidylate synthase (EfTS), w...

Neuropathology provides clues to the pathophysiology of Gaucher disease.

To better understand the pathogenesis of brain dysfunction in Gaucher disease (GD), we studied brain pathology in seven subjects with type 1 GD (four also exhibited parkinsonism and dementia), three with type 2 GD and four with type 3 GD. Unique pathologic patterns of disease involving the hippocampal CA2-4 regions and layer 4b of the calcarine cortex were identified. While these findings were ...

Structure Mapping for Jeopardy! Clues

The Jeopardy! television quiz show asks natural-language questions and requires natural-language answers. One useful source of information for answering Jeopardy! questions is text from written sources such as encyclopedias or news articles. A text passage may partially or fully indicate that some candidate answer is the correct answer to the question. Recognizing whether it does requires deter...

Suffixes as Deep Structure Clues